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The Impact of Cachexia and Sarcopenia in Elderly Pancreatic Cancer Patients Receiving Palliative Chemotherapy by Tsuyoshi Takeda; Takashi Sasaki; Chisaki Suzumori; Takafumi Mie; Takaaki Furukawa; Yuto Yamada; Akiyoshi Kasuga; Masato Matsuyama; Masato Ozaka; Naoki Sasahira is a Medicine article available to read on EtoBox.
What is The Impact of Cachexia and Sarcopenia in Elderly Pancreatic Cancer Patients Receiving Palliative Chemotherapy about?
## Background: Elderly pancreatic cancer (pc) patients are often considered vulnerable to treatment and standard treatment strategy for this subpopulation is uncertain. cachexia and sarcopenia are reported to be associated with reduced physical performance, reduced anti-tumor response, increased chemotherapy toxicity, and poor prognosis in several malignancies. the aim of this study was to evaluate the impact of cachexia and sarcopenia on the clinical course of elderly pc patients receiving chemotherapy. ## Methods: We retrospectively investigated consecutive elderly metastatic pc patients (≥ 75 years) treated with chemotherapy at our institution between january 2015 and april 2020. skeletal muscle index was calculated at the third lumbar vertebra using pretreatment computed tomography. we evaluated time to treatment failure (ttf), progression-free survival (pfs), overall survival (os), early treatment discontinuation, relative dose intensity (rdi), and severe adverse events (aes). ## Results: Among 80 patients included (gemcitabine plus nab-paclitaxel [gnp] 52; gemcitabine 21; s1 6; modified folfirinox 1), cachexia and sarcopenia were present in 48 (60%) and 61 (76%) patients, res
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- Author
- Tsuyoshi Takeda; Takashi Sasaki; Chisaki Suzumori; Takafumi Mie; Takaaki Furukawa; Yuto Yamada; Akiyoshi Kasuga; Masato Matsuyama; Masato Ozaka; Naoki Sasahira
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)