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Can I read Hypoglycemic, Antiglycation, and Cytoprotective Properties of a Phenol-Rich Extract From Waste Peel of Punica granatum L. var. Dente di Cavallo DC2 on EtoBox?
Hypoglycemic, Antiglycation, and Cytoprotective Properties of a Phenol-Rich Extract From Waste Peel of Punica granatum L. var. Dente di Cavallo DC2 by Antonella Di Sotto; Marcello Locatelli; Alberto Macone; Chiara Toniolo; Stefania Cesa; Simone Carradori; Margherita Eufemi; Gabriela Mazzanti; Silvia Di Giacomo is a Chemistry article available to read on EtoBox.
What is Hypoglycemic, Antiglycation, and Cytoprotective Properties of a Phenol-Rich Extract From Waste Peel of Punica granatum L. var. Dente di Cavallo DC2 about?
Pomegranate peel is a natural source of phenolics, claimed to possess healing properties, among which are antioxidant and antidiabetic. In the present study, an ethyl acetate extract, obtained by Soxhlet from the peel of Dente di Cavallo DC2 pomegranate (PGE) and characterized to contain 4% w/w of ellagic acid, has been evaluated for its hypoglycemic, antiglycation, and antioxidative cytoprotective properties, in order to provide possible evidence for future nutraceutical applications. The α-amylase and α-glucosidase enzyme inhibition, interference with advanced glycation end-products (AGE) formation, and metal chelating abilities were studied. Moreover, the possible antioxidant cytoprotective properties of PGE under hyperglycemic conditions were assayed. Phenolic profile of the extract was characterized by integrated chromatographic and spectrophotometric methods. PGE resulted able to strongly inhibit the tested enzymes, especially α-glucosidase, and exerted chelating and antiglycation properties. Also, it counteracted the intracellular oxidative stress under hyperglycemic conditions, by reducing the levels of reactive oxygen species and total glutathione. Among the identified phe
Who reads Hypoglycemic, Antiglycation, and Cytoprotective Properties of a Phenol-Rich Extract From Waste Peel of Punica granatum L. var. Dente di Cavallo DC2?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Antonella Di Sotto; Marcello Locatelli; Alberto Macone; Chiara Toniolo; Stefania Cesa; Simone Carradori; Margherita Eufemi; Gabriela Mazzanti; Silvia Di Giacomo
- Publisher
- MDPI AG
- Published
- 2019
- Language
- EN
- Field
- Chemistry (Life Sciences)