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Can I read Radiographical Assessment of Tumour Stroma and Treatment Outcomes Using Deep Learning: a Retrospective, Multicohort Study on EtoBox?

Radiographical Assessment of Tumour Stroma and Treatment Outcomes Using Deep Learning: a Retrospective, Multicohort Study by Jiang, Yuming (author);Liang, Xiaokun (author);Han, Zhen (author);Wang, Wei (author);Xi, Sujuan (author);Li, Tuanjie (author);Chen, Chuanli (author);Yuan, Qingyu (author);Li, Na (author);Yu, Jiang (author);Xie, Yaoqin (author);Xu, Yikai (author);Zhou, Zhiwei (author);Poultsides, George A (author);Li, Guoxin (author);Li, Ruijiang (author) is a Medicine article available to read on EtoBox.

What is Radiographical Assessment of Tumour Stroma and Treatment Outcomes Using Deep Learning: a Retrospective, Multicohort Study about?

## Background: The tumour stroma microenvironment plays an important part in disease progression and its composition can influence treatment response and outcomes. histological evaluation of tumour stroma is limited by access to tissue, spatial heterogeneity, and temporal evolution. we aimed to develop a radiological signature for non-invasive assessment of tumour stroma and treatment outcomes. ## Methods: In this multicentre, retrospective study, we analysed ct images and outcome data of 2209 patients with resected gastric cancer from five independent cohorts recruited from two centres (nanfang hospital of southern medical university [guangzhou, china] and sun yat-sen university cancer center [guangzhou, china]). patients with histologically confirmed gastric cancer, at least 15 lymph nodes harvested, preoperative abdominal ct available, and complete clinicopathological and follow-up data were eligible for inclusion. tumour tissue was collected for patients in the training cohort (321 patients), internal validation cohort one (246 patients), and external validation cohort one (128 patients). four stroma classes were defined according to the protein expression of α-smooth muscle ac

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Author
Jiang, Yuming (author);Liang, Xiaokun (author);Han, Zhen (author);Wang, Wei (author);Xi, Sujuan (author);Li, Tuanjie (author);Chen, Chuanli (author);Yuan, Qingyu (author);Li, Na (author);Yu, Jiang (author);Xie, Yaoqin (author);Xu, Yikai (author);Zhou, Zhiwei (author);Poultsides, George A (author);Li, Guoxin (author);Li, Ruijiang (author)
Publisher
Elsevier BV
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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