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Can I read Anti‐Hu paraneoplastic syndrome presenting with brainstem‐cerebellar symptoms and Lambert–Eaton myasthenic syndrome on EtoBox?
Anti‐Hu paraneoplastic syndrome presenting with brainstem‐cerebellar symptoms and Lambert–Eaton myasthenic syndrome by Toshiko Nagashima; Yasuyuki Mizutani; Hiromasa Kawahara; Shiro Maguchi; Yoshihiko Terayama; Toshiya Shinohara; Yasuko Orba; Takayo Chuma; Yukio Mano; Tomoo Itoh; Hirofumi Sawa; Koichiro Sakai; Masakatsu Motomura; Kazuo Nagashima is a Medicine article available to read on EtoBox.
What is Anti‐Hu paraneoplastic syndrome presenting with brainstem‐cerebellar symptoms and Lambert–Eaton myasthenic syndrome about?
Paraneoplastic syndrome (PNS) with two distinct neurological features was reported in a 50‐year‐old man who presented initially with vertigo, ataxia, dysarthria, tremor, confusion, urinary retention and hypotension. Pulmonary X‐ray findings, class IIIb sputum cytology, and positive anti‐Hu antibody established the diagnosis of PNS associated with small‐cell lung cancer (SCLC). Two cycles of combined chemotherapy resulted in shrinkage of the lung tumor together with complete recovery of neurological symptoms and disappearance of anti‐Hu antibody. Relapse of SCLC 4 months later with re‐appearance of anti‐Hu antibody required additional chemotherapy and irradiation. Eight months later, when multiple liver metastasis of SCLC was noticed, muscular weakness with positive waxing phenomenon compatible with Lambert–Eaton myasthenic syndrome (LEMS) developed. Postmortem examinations revealed residual SCLC in the primary lung, and massive liver metastasis with generalized lymph node involvement, but no tumors in the CNS. In the cerebellum, there was a slight loss of Purkinje cells with torpedo formation but without apparent lymphocytic infiltration. The present PNS was unique in that the rela
Who reads Anti‐Hu paraneoplastic syndrome presenting with brainstem‐cerebellar symptoms and Lambert–Eaton myasthenic syndrome?
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- Author
- Toshiko Nagashima; Yasuyuki Mizutani; Hiromasa Kawahara; Shiro Maguchi; Yoshihiko Terayama; Toshiya Shinohara; Yasuko Orba; Takayo Chuma; Yukio Mano; Tomoo Itoh; Hirofumi Sawa; Koichiro Sakai; Masakatsu Motomura; Kazuo Nagashima
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0919-6544)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)