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Can I read Novel 18β-Glycyrrhetinic Acid Analogues as Potent and Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenases on EtoBox?
Novel 18β-Glycyrrhetinic Acid Analogues as Potent and Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenases by Xiangdong Su; Harshani Lawrence; Dharshini Ganeshapillai; Adrian Cruttenden; Atul Purohit; Michael J Reed; Nigel Vicker; Barry V.L Potter is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Novel 18β-Glycyrrhetinic Acid Analogues as Potent and Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenases about?
Extensive structural modifications to the 18b-glycyrrhetinic acid template are described and their effects on the SAR of the 11b-hydroxysteroid dehydrogenase isozymes type 1 and 2 from the rat are investigated. Isoform selective inhibitors have been discovered and compound 7 N-(2-hydroxyethyl)-3b-hydroxy-11-oxo-18b-olean-12-en-30-oic acid amide is highlighted as a very potent selective inhibitor of 11b-hydroxysteroid dehydrogenase 2 with an IC 50 1⁄4 4 pM.
Who reads Novel 18β-Glycyrrhetinic Acid Analogues as Potent and Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenases?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Xiangdong Su; Harshani Lawrence; Dharshini Ganeshapillai; Adrian Cruttenden; Atul Purohit; Michael J Reed; Nigel Vicker; Barry V.L Potter
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)