Opening book details…
Can I read 3D Porous Gelatin/PVA Hydrogel as Meniscus Substitute Using Alginate Micro-Particles as Porogens on EtoBox?
3D Porous Gelatin/PVA Hydrogel as Meniscus Substitute Using Alginate Micro-Particles as Porogens by Alessandra Marrella; Alberto Lagazzo; Elena Dellacasa; Camilla Pasquini; Elisabetta Finocchio; Fabrizio Barberis; Laura Pastorino; Paolo Giannoni; Silvia Scaglione is a Materials Science article available to read on EtoBox.
What is 3D Porous Gelatin/PVA Hydrogel as Meniscus Substitute Using Alginate Micro-Particles as Porogens about?
One of the current major challenges in orthopedic surgery is the treatment of meniscal lesions. Some of the main issues include mechanical consistency of meniscal implants, besides their fixation methods and integration with the host tissues. To tackle these aspects we realized a micro-porous, gelatin/polyvinyl alcohol (PVA)-based hydrogel to approach the high percentage of water present in the native meniscal tissue, recapitulating its biomechanical features, and, at the same time, realizing a porous implant, permissive to cell infiltration and tissue integration. In particular, we adopted aerodynamically-assisted jetting technology to realize sodium alginate micro-particles with controlled dimensions to be used as porogens. The porous hydrogels were realized through freezing-thawing cycles, followed by alginate particles leaching. Composite hydrogels showed a high porosity (74%) and an open porous structure, while preserving the elasticity behavior ( = 0.25 MPa) and high water content, typical of PVA-based hydrogels. The ex vivo animal model validation proved that the addition of gelatin, combined with the micro-porosity of the hydrogel, enhanced implant integration with the host
Who reads 3D Porous Gelatin/PVA Hydrogel as Meniscus Substitute Using Alginate Micro-Particles as Porogens?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Alessandra Marrella; Alberto Lagazzo; Elena Dellacasa; Camilla Pasquini; Elisabetta Finocchio; Fabrizio Barberis; Laura Pastorino; Paolo Giannoni; Silvia Scaglione
- Published
- 2018
- Language
- EN
- Field
- Materials Science (Physical Sciences)