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L’atteinte des articulations métacarpophalangiennes est une localisation fréquente au cours de l’arthrose digitale : résultats de la cohorte DIGICOD by Kouki, I.; Tuffet, S.; Crema, M.; Rousseau, A.; Richette, P.; Dougados, M.; Berenbaum, F.; Sellam, J.; Courties, A. is a Medicine article available to read on EtoBox.

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There is growing interest in assessing possible immunotoxicological effects in anesthetized patients. There are controversial findings concerning the effect of nitrous oxide (N 2 O) anesthetic gas effect on inflammatory response. We tested the hypothesis that N 2 O associated with desflurane (inhalational anesthetic) was likely to worsen neuro-immune-endocrine effects when compared with desflurane alone in this randomized trial. The primary endpoint of this study was to evaluate the systemic proinflammatory interleukin (IL)-6, and the secondary endpoints included other systemic (IL-1β, TNF-α, IL-8, IL-10, IL-17A and high-sensitivity C-reactive proteinhs-CRP) and genetic inflammatory markers (NF-kB, IL-6 and COX-2) as well as hormones (adrenocorticotropic hormone, cortisol and prolactin) comparing patients undergoing minor surgery with or without N 2 O-desflurane. As a second aim, we assessed whether there were changes in the neuro-immune-endocrine profiles within each group. Blood samples were collected before anesthesia, 90 min after anesthesia induction, and the day after surgery. We assessed serum cytokines using a cytometric bead array and hs-CRP by chemiluminescent immunoassay

Who reads L’atteinte des articulations métacarpophalangiennes est une localisation fréquente au cours de l’arthrose digitale : résultats de la cohorte DIGICOD?

Author

Kouki, I.; Tuffet, S.; Crema, M.; Rousseau, A.; Richette, P.; Dougados, M.; Berenbaum, F.; Sellam, J.; Courties, A.

Publisher

Elsevier Science; Elsevier ; Elsevier Masson; Elsevier BV (ISSN 1169-8330)

Published

2020

Language

FR

Field

Medicine (Health Sciences)