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An NAD þ -dependent D-xylose dehydrogenase, XylB, from Caulobacter crescentus was expressed in Saccharomyces cerevisiae, resulting in production of 177 2 g D-xylonate l À 1 at 0.23 g l À 1 h À 1 from 23 g D-xylose l À 1 (with glucose and ethanol as co-substrates). D-Xylonate titre and production rate were increased and xylitol production decreased, compared to strains expressing genes encoding T. reesei or pig liver NADP þ -dependent D-xylose dehydrogenases. D-Xylonate accumulated intracellularly to $ 70 mg g À 1 ; xylitol to $ 18 mg g À 1 . The aldose reductase encoding gene GRE3 was deleted to reduce xylitol production. Cells expressing D-xylonolactone lactonase xylC from C. crescentus with xylB initially produced more extracellular D-xylonate than cells lacking xylC at both pH 5.5 and pH 3, and sustained higher production at pH 3. Cell vitality and viability decreased during D-xylonate production at pH 3.0. An industrial S. cerevisiae strain expressing xylB efficiently produced 43 g D-xylonate l À 1 from 49 g D-xylose l À 1 .

Author

H.D. Holland; K.K. Turekian

Publisher

Elsevier

Published

2003

Language

EN