About this Medicine article

Long-term high intake of 9-PAHPA or 9-OAHPA increases basal metabolism and insulin sensitivity but disrupts liver homeostasis in healthy mice by Melha Benlebna; Laurence Balas; Béatrice Bonafos; Laurence Pessemesse; Claire Vigor; Jacques Grober; Florence Bernex; Gilles Fouret; Veronika Paluchova; Sylvie Gaillet; Jean François Landrier; Ondrej Kuda; Thierry Durand; Charles Coudray; François Casas; Christine Feillet-Coudray is a Medicine article available to read on EtoBox.

Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a new family of endogenous lipids recently discovered. Several studies reported that some FAHFAs have antidiabetic and anti-inflammatory effects. The objective of this study was to explore the impact of two FAHFAs, 9-PAHPA or 9-OAHPA, on the metabolism of mice. C57Bl/6J male mice, 6 weeks old, were divided into 3 groups of 10 mice each. One group received a control diet and the two others groups received the control diet supplemented with 9-PAHPA or 9-OAHPA for 12 weeks. Mouse weight and body composition were monitored throughout the study. Some days before euthanasia, energy expenditure, glucose tolerance and insulin sensitivity were also determined. After sacrifice, blood and organs were collected for relevant molecular, biochemical and histological analyses. Although high intake of 9-PAHPA or 9-OAHPA increased basal metabolism, it had no direct effect on body weight. Interestingly, the 9-PAHPA or 9-OAHPA intake increased insulin sensitivity but without modifying glucose tolerance. Nevertheless, 9-PAHPA intake induced a loss of glucose-stimulated insulin secretion. Surprisingly, both studied FAHFAs induced hepatic ste

Author

Melha Benlebna; Laurence Balas; Béatrice Bonafos; Laurence Pessemesse; Claire Vigor; Jacques Grober; Florence Bernex; Gilles Fouret; Veronika Paluchova; Sylvie Gaillet; Jean François Landrier; Ondrej Kuda; Thierry Durand; Charles Coudray; François Casas; Christine Feillet-Coudray

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0955-2863)

Published

2020

Language

EN

Field

Medicine (Health Sciences)