Can I read EOLIA trial: the future of extracorporeal membrane oxygenation in acute respiratory distress syndrome therapy? on EtoBox?

EOLIA trial: the future of extracorporeal membrane oxygenation in acute respiratory distress syndrome therapy? by Muhammad Sameed; Zhou Meng; Ellen T. Marciniak is a Medicine article available to read on EtoBox.

What is EOLIA trial: the future of extracorporeal membrane oxygenation in acute respiratory distress syndrome therapy? about?

This was a prospective, multi-centre randomised controlled trial that involved centres in 16 countries. The trial was designed as a group sequential analysis with data analysed after randomisation of every 60 participants; stopping rules were predefined using the two triangle method. The trial could be stopped due to safety (due to excessive mortality in the ECMO arm), efficacy or futility (if unlikely to reach a definitive result). The trial was designed to have a power of 80% and alpha level of 5% to detect an absolute risk reduction of 20%. It was hypothesised that the mortality would be 60% in the conventional arm and 40% in the ECMO arm. Mortality at 60 days was the primary outcome measured.

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Author

Muhammad Sameed; Zhou Meng; Ellen T. Marciniak

Publisher

European Respiratory Society ; European Respiratory Society (ERS) (ISSN 1810-6838)

Published

2019

Language

EN

Field

Medicine (Health Sciences)