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Erosive hand osteoarthritis and sarcopenia: data from Osteoarthritis Initiative cohort by Kamyar Moradi; Robert M Kwee; Bahram Mohajer; Ali Guermazi; Frank W Roemer; Hamza Ahmed Ibad; Ida K Haugen; Francis Berenbaum; Shadpour Demehri is a Medicine article available to read on EtoBox.

What is Erosive hand osteoarthritis and sarcopenia: data from Osteoarthritis Initiative cohort about?

## Objectives There is no evidence linking specific osteoarthritis (OA) types, such as erosive hand OA (EHOA), with distant generalised changes in muscle composition (sarcopenia), which can potentially be modified. This study pioneers the exploration of the association between EHOA and sarcopenia, both of which are predominantly observed in the older adults. ## Methods Using the Osteoarthritis Initiative cohort, we selected hand OA (modified Kellgren and Lawrence (grade ≥2 in ≥1 hand joint) participants with radiographic central erosions in ≥1 joints (EHOA group) and propensity score-matched hand OA participants with no erosion (non-EHOA group). MRI biomarkers of thigh muscles were measured at baseline, year 2 and year 4 using a validated deep-learning algorithm. To adjust for ‘local’ effects of coexisting knee OA (KOA), participants were further stratified according to presence of radiographic KOA. The outcomes were the differences between EHOA and non-EHOA groups in the 4-year rate of change for both intramuscular adipose tissue (intra-MAT) deposition and contractile (non-fat) area of thigh muscles. ## Results After adjusting for potential confounders, 844 thighs were included (2

Who reads Erosive hand osteoarthritis and sarcopenia: data from Osteoarthritis Initiative cohort?

Author

Kamyar Moradi; Robert M Kwee; Bahram Mohajer; Ali Guermazi; Frank W Roemer; Hamza Ahmed Ibad; Ida K Haugen; Francis Berenbaum; Shadpour Demehri

Publisher

BMJ

Published

2024

Language

EN

Field

Medicine (Health Sciences)