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Isolation, characterization and anticancer activity of secondary metabolites from Verbascum speciosum by Serpil Demirci; Cemalettin Alp; Hüseyin Akşit; Yakup Ulutaş; Ahmet Altay; Esma Yeniçeri; Ekrem Köksal; Nurettin Yaylı is a Chemistry article available to read on EtoBox.
What is Isolation, characterization and anticancer activity of secondary metabolites from Verbascum speciosum about?
Herein, two iridoid glucosides aucubin (1) and ajugol (2), and two phenyl ethanoids, verbascoside (3) and poliumoside (4) were isolated from the methanol extract of the aerial parts of Verbascum speciosum and used to study about their anticancer activity for the first time. The structures of all compounds were elucidated using spectroscopic data (IR, 1D and 2D NMR, LC-TOF/MS). Antiproliferative activities of Aucubun ( 1 ) and Verbascoside (3) were tested against A-549 (human colon cancer), MDA-MD-453 (human breast cancer) and 3T3-L1 (mouse fibroblast)cell lines by XTT assay. In addition, the anticarcer mechanism of action of aucubin (1) was investigated on MDA-MB-453 cells for the first time. XTT result showed that both applied compounds exhibited antiproliferative effect at different dose ranges depending on the cancer type, as well as selectivity between cancer and healty cell lines. Flow cytometry analyzes revealed that aucubin (1) exerts its cytotoxic effect in MDA-MB-453 cells by directing cells to early apoptosis and inhibiting the P13K/AKT signaling pathway.
Who reads Isolation, characterization and anticancer activity of secondary metabolites from Verbascum speciosum?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Serpil Demirci; Cemalettin Alp; Hüseyin Akşit; Yakup Ulutaş; Ahmet Altay; Esma Yeniçeri; Ekrem Köksal; Nurettin Yaylı
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Physical Sciences)