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Can I read Attempts to detect virus-specific DNA in human tumors. II. Nucleic acid hybridizations with complementary RNA of human herpes group viruses on EtoBox?
Attempts to detect virus-specific DNA in human tumors. II. Nucleic acid hybridizations with complementary RNA of human herpes group viruses by Harald Zur Hausen; Heinrich Schulte-Holthausen; Hans Wolf; Kristina Dörries; Herwig Egger is a Medicine article available to read on EtoBox.
What is Attempts to detect virus-specific DNA in human tumors. II. Nucleic acid hybridizations with complementary RNA of human herpes group viruses about?
## Abstract DNA derived from various human malignant and non‐malignant tissues was hybridized with radioactive complementary RNA (cRNA) synthetized in vitro with the aid of E.coli‐RNA‐polymerase by using DNA of human herpes group viruses as templates. Epstein‐Barr virus (EBV)‐specific cRNA annealed significantly with DNA from nasopharyngeal carcinoma biopsies as well as with DNA preparations from leukocytes, bone marrow, lymph node and spleen of some patients with infectious mononucleosis. No significant hybridization was observed with either herpes simplex type 2 or type 1 cRNA and DNA from ten cervical carcinoma biopsies. cRNA of human cytomegalovirus and varicellazoster virus did not hybridize with DNA from Kaposi's sarcoma or DNA from heavily infiltrated spleens of patients with Hodgkin's disease. These data do not exclude a role of these herpes viruses in the etiology of cervical carcinoma, Kaposi's sarcoma and Hodgkin's disease. They show, however, that such a relationship (if it exists) must differ quantitatively to a considerable extent from the one observed with EBV in EBV‐associated tumors.
Who reads Attempts to detect virus-specific DNA in human tumors. II. Nucleic acid hybridizations with complementary RNA of human herpes group viruses?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Harald Zur Hausen; Heinrich Schulte-Holthausen; Hans Wolf; Kristina Dörries; Herwig Egger
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1974
- Language
- EN
- Field
- Medicine (Health Sciences)