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On the Co‐occurrence of Startles and Hippocampal Sharp Waves in Newborn Rats by Karl Æ. Karlsson; Ethan J. Mohns; Gonzalo Viana di Prisco; Mark S. Blumberg is a Neuroscience article available to read on EtoBox.

What is On the Co‐occurrence of Startles and Hippocampal Sharp Waves in Newborn Rats about?

## Abstract Hippocampal sharp waves (SPWs) are among the earliest neural population patterns observed in infant mammals. Similarly, startles are among the earliest behavioral events observed. Here we provide evidence indicating that these two events are linked mechanistically soon after birth in freely moving and head‐fixed 1 to 4‐day‐old rats. EMG electrodes and intrahippocampal silicon depth electrodes were used to detect the presence of startles and SPWs, respectively. In intact pups, the majority of sharp waves were preceded by startles (average latency: 161 ms). When the hippocampal formation was surgically separated from the brainstem, however, sharp waves and startles still occurred, but now independently. In addition, unrelated to startles or SPWs, gamma oscillations were detected in several subjects, as were neocortical “spindles” that propagated passively into the hippocampus. The cooccurrence of sharp waves and startles provides the opportunity for Hebbian changes in synaptic efficacy and, thus, is poised to contribute to the assembly of neural circuits early in development. © 2006 Wiley‐Liss, Inc.

Who reads On the Co‐occurrence of Startles and Hippocampal Sharp Waves in Newborn Rats?

Author

Karl Æ. Karlsson; Ethan J. Mohns; Gonzalo Viana di Prisco; Mark S. Blumberg

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

2006

Language

EN

Field

Neuroscience (Life Sciences)