About this Pharmacology, Toxicology and Pharmaceutics article
Recent Advances in Curcumin Nanoformulation for Cancer Therapy by Wing-Hin Lee; Ching-Yee Loo; Paul M Young; Daniela Traini; Rebecca S Mason; Ramin Rohanizadeh is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
## Introduction: Natural compounds are emerging as effective agents for the treatment of malignant diseases. curcumin (diferuloylmethane), the active constituent of turmeric extract, has gained significant interest as a plant-based compound with anti-cancer properties. curcumin is physiologically very well tolerated, with negligible systemic toxicity observed even after high oral doses administration. despite curcumin's superior properties as an anti-cancer agent its applications are limited due to its low solubility and physico-chemical stability, rapid systemic clearance and low cellular uptake. ## Areas covered: This review focuses on the development of curcumin nano-particle formulation to improve its therapeutic index through enhanced cellular uptake, localization to targeted areas and improved bioavailability. the feasibility of nano-formulation in delivering curcumin and the limitations and challenges in designing and administrating the nano-sized curcumin particles are also covered in this review. ## Expert opinion: Nanotechnology is a promising tool to enhance efficacy and delivery of drugs. in this context, formulation of curcumin as nano-sized particles could reduce the
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Wing-Hin Lee; Ching-Yee Loo; Paul M Young; Daniela Traini; Rebecca S Mason; Ramin Rohanizadeh
- Publisher
- Informa Healthcare
- Published
- 2014
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)