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Can I read Catechin as an antioxidant in liver mitochondrial toxicity: Inhibition of tamoxifen‐Induced protein oxidation and lipid peroxidation on EtoBox?
Catechin as an antioxidant in liver mitochondrial toxicity: Inhibition of tamoxifen‐Induced protein oxidation and lipid peroxidation by Heena Tabassum; Suhel Parvez; Hasibur Rehman; Basu Dev Banerjee; Sheikh Raisuddin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Catechin as an antioxidant in liver mitochondrial toxicity: Inhibition of tamoxifen‐Induced protein oxidation and lipid peroxidation about?
## Abstract Tamoxifen (TAM) is a nonsteroidal triphenylethylene antiestrogenic drug widely used in the treatment and prevention of breast cancer. TAM brings about a collapse of the mitochondrial membrane potential. It acts both as an uncoupling agent and as a powerful inhibitor of mitochondrial electron transport chain. The effect of catechin pretreatment on the mitochondrial toxicity of TAM was studied in liver mitochondria of Swiss albino mice. TAM treatment caused a significant increase in the mitochondrial lipid peroxidation (LPO) and the protein carbonyls (PCs). It also caused a significant increase in superoxide radical production. Pretreatment of mice with catechin (40 mg/kg) showed significant protection as demonstrated by marked attenuation of increased oxidative stress parameters such LPO, PCs, and superoxide production. It also restored the decreased nonenzymatic and enzymatic antioxidants of mitochondria. The inhibitory effect of catechin on TAM‐induced oxidative damage suggests that it may have potential benefits in prevention of human diseases where reactive oxygen species have some role as causative agents. © 2007 Wiley Periodicals, Inc. J Biochem Mol Toxicol 21:110–
Who reads Catechin as an antioxidant in liver mitochondrial toxicity: Inhibition of tamoxifen‐Induced protein oxidation and lipid peroxidation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Heena Tabassum; Suhel Parvez; Hasibur Rehman; Basu Dev Banerjee; Sheikh Raisuddin
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1095-6670)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)