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Genomic Correlation, Shared Loci, and Causal Relationship Between Obesity and Polycystic Ovary Syndrome: a Large-scale Genome-wide Cross-trait Analysis by Qianwen Liu; Zhaozhong Zhu; Peter Kraft; Qiaolin Deng; Elisabet Stener-Victorin; Xia Jiang is a Medicine article available to read on EtoBox.

What is Genomic Correlation, Shared Loci, and Causal Relationship Between Obesity and Polycystic Ovary Syndrome: a Large-scale Genome-wide Cross-trait Analysis about?

## Abstract ## Background The comorbidity between polycystic ovary syndrome (PCOS) and obesity has long been observed in clinical settings, but their shared genetic basis remains unclear. ## Methods Leveraging summary statistics of large-scale GWAS(s) conducted in European-ancestry populations on body mass index (adult BMI, N~female~=434,794; childhood BMI, N=39,620), waist-to-hip ratio (WHR, N~female~=381,152), WHR adjusted for BMI (WHR~adj~BMI, N~female~=379,501), and PCOS (N~case~=10,074, N~control~=103,164), we performed a large-scale genome-wide cross-trait analysis to quantify overall and local genetic correlation, to identify shared loci, and to infer causal relationship. ## Results We found positive genetic correlations between PCOS and adult BMI (r~g~=0.47, P=2.19×10^−16^), childhood BMI (r~g~=0.31, P=6.72×10^−5^), and WHR (r~g~=0.32, P=1.34×10^−10^), all withstanding Bonferroni correction. A suggestive significant genetic correlation was found between PCOS and WHR~adj~BMI (r~g~=0.09, P=0.04). Partitioning the whole genome into 1703 nearly independent regions, we observed a significant local genetic correlation for adult BMI and PCOS at chromosome 18: 57630483–59020751. We

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Author

Qianwen Liu; Zhaozhong Zhu; Peter Kraft; Qiaolin Deng; Elisabet Stener-Victorin; Xia Jiang

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)