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Can I read Repurposing N-acetylcysteine for management of non-acetaminophen induced acute liver failure: an evidence scan from a global health perspective on EtoBox?
Repurposing N-acetylcysteine for management of non-acetaminophen induced acute liver failure: an evidence scan from a global health perspective by Rebecca N. Jerome; Laura A. Zahn; Jessica J. Abner; Meghan M. Joly; Jana K. Shirey-Rice; Robert S. Wallis; Gordon R. Bernard; Jill M. Pulley is a Medicine article available to read on EtoBox.
What is Repurposing N-acetylcysteine for management of non-acetaminophen induced acute liver failure: an evidence scan from a global health perspective about?
## Background The World Health Organization (WHO)’s Essential Medicines List (EML) plays an important role in advocating for access to key treatments for conditions affecting people in all geographic settings. We applied our established drug repurposing methods to one EML agent, N-acetylcysteine (NAC), to identify additional uses of relevance to the global health community beyond its existing EML indication (acetaminophen toxicity). ## Methods We undertook a phenome-wide association study (PheWAS) of a variant in the glutathione synthetase (__GSS__) gene in approximately 35,000 patients to explore novel indications for use of NAC, which targets glutathione. We then evaluated the evidence regarding biologic plausibility, efficacy, and safety of NAC use in the new phenotype candidates. ## Results PheWAS of __GSS__ variant R418Q revealed increased risk of several phenotypes related to non-acetaminophen induced acute liver failure (ALF), indicating that NAC may represent a therapeutic option for treating this condition. Evidence review identified practice guidelines, systematic reviews, clinical trials, retrospective cohorts and case series, and case reports. This evidence suggesting b
Who reads Repurposing N-acetylcysteine for management of non-acetaminophen induced acute liver failure: an evidence scan from a global health perspective?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Rebecca N. Jerome; Laura A. Zahn; Jessica J. Abner; Meghan M. Joly; Jana K. Shirey-Rice; Robert S. Wallis; Gordon R. Bernard; Jill M. Pulley
- Publisher
- AME Publishing Company
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)