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Time-resolved Autofluorescence Spectroscopy for Classifying Normal and Premalignant Oral Tissues by Hsin-Ming Chen; Chun-Pin Chiang; Chun You; Tzu-Chien Hsiao; Chih-Yu Wang is a Medicine article available to read on EtoBox.

What is Time-resolved Autofluorescence Spectroscopy for Classifying Normal and Premalignant Oral Tissues about?

## Background and objectives: Time-resolved autofluorescence spectroscopy has been used for effectively distinguishing normal tissues from precancers and cancers in various organs. the aim of this study was to find out the possibility of using time-resolved autofluorescence spectroscopy to differentiate normal oral mucosa (nom) from oral premalignant lesions including verrucous hyperplasia (vh), epithelial hyperplasia (eh), and epithelial dysplasia (ed). ## Study design/materials and methods: Time-resolved autofluorescence spectra at 633 nm under 410-nm excitation were recorded for 15 vh, 9 eh, 14 ed, and 38 nom samples. the two-component lifetimes of the obtained curves were calculated, and a fisher's discriminant analysis (fda) was employed for distinguishing these tissue samples. ## Results: After two-component lifetimes for all samples being calculated, a two-dimensional scatter plot was developed, in which 76 oral tissue samples were separated into three groups by fda. with a leave-one-out method, the fda algorithm gave an accuracy rate of 93% for ed, of 75% for vh and eh, and of 100% for nom samples. in addition, all oral premalignant lesions (including vh, eh, and ed) could

Who reads Time-resolved Autofluorescence Spectroscopy for Classifying Normal and Premalignant Oral Tissues?

Author

Hsin-Ming Chen; Chun-Pin Chiang; Chun You; Tzu-Chien Hsiao; Chih-Yu Wang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0196-8092)

Published

2005

Language

EN

Field

Medicine (Health Sciences)