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Newly Uncovered Biochemical and Functional Aspects of Ferritin by Izumi Yanatori; Sohji Nishina; Fumio Kishi; Keisuke Hino is a Medicine article available to read on EtoBox.

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## Abstract Iron homeostasis is strictly regulated at both the systemic and cellular levels by complex mechanisms because of its indispensability and toxicity. Among the various iron‐regulatory proteins, ferritin is the earliest discovered regulator of iron metabolism and is a molecule that safely retains excess intracellular iron in the cores of its shells. Two types of ferritin, cytosolic ferritin and mitochondrial ferritin (FTMT), have been identified in a range of organisms from plants to humans. FTMT was identified approximately 60 years after the discovery of cytosolic ferritin. Cytosolic ferritin expression is regulated in an iron‐responsive manner. Recently, the molecular mechanisms of iron‐dependent degradation of cytosolic ferritin or its secretion into serum have been clarified. FTMT, which shares a high degree of sequence homology with cytosolic ferritin, has distinct functions and is regulated in different ways from cytosolic ferritin. Although knowledge of the physiological role of FTMT is still incomplete, recent studies have shed light on the function and regulation of FTMT. The accumulating biological evidence of both ferritins has made it possible to deepen our kn

Who reads Newly Uncovered Biochemical and Functional Aspects of Ferritin?

Author

Izumi Yanatori; Sohji Nishina; Fumio Kishi; Keisuke Hino

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)