About this Medicine article
Synthesis of type-C virus particles from murine cultured cells induced by iododeoxyuridine. VI. Biosynthesis of reverse transcriptase by M. S. Reitz; A. M. Wu; R. C. Gallo is a Medicine article available to read on EtoBox.
## Abstract Treatment with 5‐iodo‐2'‐deoxyuridine (IdUrd) of BALB/3T3 cells non‐productively transformed with Kirsten murine sarcoma virus (K‐BALB) results in the induction of extracellular type‐C virus production with a concomitant appearance of intracellular reverse transcriptase. Production of BALB virus‐2 (v‐2) and its Kirsten sarcoma virus pseudo‐type, occurring 2‐3 days after IdUrd treatment, is inhibited and stimulated by interferon and dexamethasone, respectively, By contrast, and as previously reported, neither compound affects synthesis of N‐tropic virus (BALB virus‐1) which is produced later (5‐7 days) after IdUrd treatment. The stimulatory and inhibitory activities of these compounds are partially antagonistic since: (1) the simultaneous presence of both dexamethasone and interferon results in a virus production level between those observed with either compound alone; and (2) increasing the dexamethasone concentration at a fixed interferon concentration increases virus production. However, the effects of these two compounds on the appearance of an intracellular viral protein (reverse transcriptase) after IdUrd treatment were unexpected. The post‐induction appearance of
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- Author
- M. S. Reitz; A. M. Wu; R. C. Gallo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1977
- Language
- EN
- Field
- Medicine (Health Sciences)