Can I read Obesity Paradox, Obesity Orthodox, and the Metabolic Syndrome: An Approach to Unity on EtoBox?

Obesity Paradox, Obesity Orthodox, and the Metabolic Syndrome: An Approach to Unity by Jesse Roth; Navneet Sahota; Priya Patel; Syed F Mehdi; Mohammad M Wiese; Hafiz B Mahboob; Michelle Bravo; Daniel J Eden; Muhammad A Bashir; Amrat Kumar; Farah Alsaati; Irwin J Kurland; Wunnie Brima; Ann Danoff; Alessandra L Szulc; Valentin A Pavlov; Kevin J Tracey; Huan Yang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Obesity Paradox, Obesity Orthodox, and the Metabolic Syndrome: An Approach to Unity about?

Obesity and the accompanying metabolic syndrome are strongly associated with heightened morbidity and mortality in older adults. In our review of more than 20 epidemiologic studies of major infectious diseases, including leaders such as tuberculosis, community-acquired pneumonia, and sepsis, obesity was associated with better outcomes. A cause-and-effect relationship between over-nutrition and survival with infection is suggested by results of two preliminary studies of infections in mice, where high fat feeding for 8-10 weeks provided much better outcomes. The better outcomes of infections with obesity are reminiscent of many recent studies of "sterile" non-infectious medical and surgical conditions where outcomes for obese patients are better than for their thinner counterparts --- and given the tag "obesity paradox". Turning to the history of medicine and biological evolution, we hypothesize that the metabolic syndrome has very ancient origins and is part of a lifelong metabolic program. While part of that program (the metabolic syndrome) promotes morbidity and mortality with aging, it helps infants and children as well as adults in their fight against infections and recovery fr

Who reads Obesity Paradox, Obesity Orthodox, and the Metabolic Syndrome: An Approach to Unity?

Author

Jesse Roth; Navneet Sahota; Priya Patel; Syed F Mehdi; Mohammad M Wiese; Hafiz B Mahboob; Michelle Bravo; Daniel J Eden; Muhammad A Bashir; Amrat Kumar; Farah Alsaati; Irwin J Kurland; Wunnie Brima; Ann Danoff; Alessandra L Szulc; Valentin A Pavlov; Kevin J Tracey; Huan Yang

Publisher

The Feinstein Institute for Medical Research; Springer (Biomed Central Ltd.); North Shore - Long Jewish Research Institute; Baltimore Md.: Johns Hopkins University Press; Manhasset NY: North Shore-Long Island Jewish Research Institute; Manhasset NY: Feinstein Institute for Medical Research; [London]: BioMed Central; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Test accounts (ISSN 1076-1551)

Published

2016

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)