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B67. UNDERSTANDING LUNG INJURY: FROM GENE TO DYSFUNCTION - Estimated Gravitational Stress Is Significantly Increased in Lungs of Patients with ARDS by Kizhakke Puliyakote, A.S.; Botros, L.; Kumar, H.; Tawhai, M.H.; Bogaard, H.J.; Hopkins, S.R. is a scholarly article available to read on EtoBox.

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The lung is subject to the forces of gravity, deforming under its own weight. In patients with Acute Respiratory Distress Syndrome (ARDS), the presence of edema increases lung weight, potentially inducing higher stress on some parts of the lung due to the effects of gravity. We have previously established a simple estimate of gravitational stress, defined at a voxel as the force exerted by the cumulative weight of a column of tissue gravitationally dependent to that point. This metric may help identify regions of excessive stress imposed by gravity, that may be vulnerable to further impairment of function. Methods:Three patients with acute respiratory distress syndrome, who have undergone prone ventilation for at least 16 hours, and with a clinically available computed tomography (CT) scan at the Amsterdam UMC were retrospectively selected for this study. Lung density was quantified using CT images, acquired supine during mechanical ventilation, at end inspiration, without contrast enhancement. The open source Pulmonary Toolkit library was used for lung segmentation. Estimated gravitational stress was calculated as the ratio of total lung mass in the gravitationally dependent colum

Author

Kizhakke Puliyakote, A.S.; Botros, L.; Kumar, H.; Tawhai, M.H.; Bogaard, H.J.; Hopkins, S.R.

Publisher

American Thoracic Society

Published

2020

Language

EN