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Glycolipids of germ cell tumors: Extended globo-series glycolipids are a hallmark of human embryonal carcinoma cells by Jonathan Wenk; Peter W. Andrews; Jochen Casper; Jun-Ichi Hata; Martin F. Pera; Alexander von Keitz; Ivan Damjanov; Bruce A. Fenderson is a Medicine article available to read on EtoBox.
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## Abstract Glycolipids of human germ cell tumor lines were analyzed co define the most common immunohistochemical profiles of embryonal carcinoma (EC), differentiated derivatives of EC, yolk sac carcinoma (YC) and choriocarcinoma (CC). Glycolipid composition was examined by high‐performance thin‐layer chromatography (HPTLC) combined with Immunostaining with a panel of anti‐carbohydrate monoclonal antibodies (MAbs). All EC cell lines were found to contain high levels of globo‐series glycolipids, including globotriosylceramide (Gb3), globoside (Gb4), Gb5 (Ga1β1 ± 1Gb4) and GL7 (sialyl Ga1β1 ± 3Gb4). Somatic differentiated derivatives (e.g., EC cells treated with retinoic acid) contained decreased levels of globo‐series glycolipids and increased levels of lacto‐ and ganglio‐series glycolipids, including GD3, GT3 and GD2. CC cell lines contained relatively large amounts of Gb3 but did not contain extended globo‐series glycolipids GbS and GL7. CC cell lines also contained a macroglycolipid reactive with the antibody to SSEA‐1 (Le^x^). Glycolipids were not detected in two YC cell lines, while other YC cell lines contained globo‐series core glycolipids (Gb3 and Gb4) and gangliosides. We
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- Author
- Jonathan Wenk; Peter W. Andrews; Jochen Casper; Jun-Ichi Hata; Martin F. Pera; Alexander von Keitz; Ivan Damjanov; Bruce A. Fenderson
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1994
- Language
- EN
- Field
- Medicine (Health Sciences)