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What is Wnt Pathway Effects on TLS in CRC MMR about?

This study investigates the relationship between the Wnt signaling pathway and tertiary lymphoid structures (TLS) in colorectal cancer (CRC) patients with different mismatch repair (MMR) subtypes. It finds that the quantity and maturity of TLS, as well as tumor-resident memory T cells (TRM), vary significantly between MMR-deficient and proficient CRC, suggesting potential biomarkers for immunotherapy efficacy. The results indicate that higher β-catenin expression correlates with lower TLS quantity in dMMR C

Author

Cancer Plus

Language

EN