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Directed Aldol Reaction Mechanisms by Chemical Molecule is a document available to read on EtoBox.
The document summarizes the stereoselective aldol reaction, including: 1) The aldol reaction was discovered in 1872 and produces aldol products from carbonyl compounds. 2) Zimmerman and Traxler proposed the reaction proceeds through a chair-like transition state to give either syn or anti stereochemistry depending on the enolate geometry. 3) (Z)-enolates favor the syn-aldol adduct through minimizing 1,3-diaxial interactions in the transition state structure.
- Author
- Chemical Molecule
- Language
- EN