Can I read Serum cystatin C is not a better marker of creatinine or digoxin clearance than serum creatinine on EtoBox?

Serum cystatin C is not a better marker of creatinine or digoxin clearance than serum creatinine by S. O'Riordan; E. Ouldred; S. Brice; S. H. D. Jackson; C. G. Swift is a Medicine article available to read on EtoBox.

What is Serum cystatin C is not a better marker of creatinine or digoxin clearance than serum creatinine about?

**Aims** To assess whether cystatin C, a new serum marker of renal function, is a better index of creatinine or digoxin clearance than serum creatinine in older people. **Methods** Twenty‐two volunteers over the age of 65 years (mean 73±5) were recruited from a healthy elderly volunteer database. None of the volunteers was taking digoxin or other medication known to interfere with digoxin kinetics or assay. Digoxin was infused at a dose of 7–10 μg kg^−1^ and blood samples were taken over the following 48 h and assayed for serum digoxin. Serum cystatin C, creatinine and creatinine clearance were measured and a calculated creatinine clearance was estimated using the Cockcroft Gault formula. Digoxin clearance was calculated using a pharmacokinetic software package. All values were log transformed to normalize their distribution. **Results** Of the 22 volunteers enrolled into the study, 18 completed the study. Serum cystatin C ranged between 0.72 and 1.89 mg l^−1^ and serum creatinine ranged from 69.6 to 153.9 μmol l^−1^. Measured creatinine clearance ranged from 38 to 123 ml min^−1^ and calculated creatinine clearance from 29.5 to 88.0 ml min^−1^. Digoxin clearance ranged from 51.0 to

Who reads Serum cystatin C is not a better marker of creatinine or digoxin clearance than serum creatinine?

Author

S. O'Riordan; E. Ouldred; S. Brice; S. H. D. Jackson; C. G. Swift

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)

Published

2002

Language

EN

Field

Medicine (Health Sciences)