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HLA-DP/DR interaction in early onset pauciarticular juvenile chronic arthritis by Christian Paul; Ulrich Schoenwald; Hans Truckenbrodt; Maria P. Bettinotti; Günter Brünnler; Elisabeth Keller; Claudia Nevinny-Stickel; Zhu Yao; Ekkehard D. Albert is a Immunology and Microbiology article available to read on EtoBox.

What is HLA-DP/DR interaction in early onset pauciarticular juvenile chronic arthritis about?

We investigated the polymorphic second exon of the HLA-DPB1 and HLA-DRB1 genes, using in vitro DNA amplification by polymerase chain reaction (PCR) and oligonucleotide hybridization in 136 patients with early onset pauciarticular juvenile chronic arthritis (EOPA-JCA) and 199 healthy controls. The analysis of the HLA-DRB1 system revealed that most of the DRB1 alleles are not indifferent with respect to susceptibility to EOPA-JCA. There is a hierarchy of susceptible (DRB1\*08, DR5), "permissive" (DRB1\*01), moderately "protective" (DR2, DRB1\*04), and "protective" (DRB1\*07) alleles. In contrast, no hierarchy could be shown for the HLA-DPB1 system. DPB1\*0201 was found to be susceptible. The relatively frequent alleles DPB1\*0402 and DPB1\*0401 seem to be indifferent. The associations with DPB1\*0201, DR5, and DRB1\*08 are independent of each other: that is to say they, are not brought about by linkage disequilibrium. The susceptible alleles DPB1\*0201 and DR5 show evidence for interaction in the pathogenesis of EOPA-JCA. Interaction seems likely between DPB1\*0201 and DRB1\*08, DR5 and DRB1\*08, or between DR6 and DRB1\*08. The strongest interaction exists between DPB1\*0201 and a c

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Author

Christian Paul; Ulrich Schoenwald; Hans Truckenbrodt; Maria P. Bettinotti; Günter Brünnler; Elisabeth Keller; Claudia Nevinny-Stickel; Zhu Yao; Ekkehard D. Albert

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0093-7711)

Published

1993

Language

EN

Field

Immunology and Microbiology (Life Sciences)