Opening book details…
Can I read A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats on EtoBox?
A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats by Heli Karhunen; Jari Nissinen; Juhani Sivenius; Jukka Jolkkonen; Asla Pitkänen is a Medicine article available to read on EtoBox.
What is A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats about?
The aim was to test the hypothesis that occlusion of the middle cerebral artery (MCA) results in the development of epilepsy in rats. Further, we investigated whether lesion volume, hippocampal pathology, early seizures, or severity of behavioral impairment is associated with the development and severity of epilepsy or interictal spiking. MCA occlusion was induced by intracerebral injection of endothelin-1 (ET; 120 pmol). One group of ET-injected rats were followed-up for 6 months (n = 15) and another for 12 months (n = 20). Sham-operated animals were injected with saline (n = 12). Occurrence of early and late seizures was monitored by intermittent video-electroencephalography. Sensorimotor function was tested with the running wheel and tapered beam-walking tests. Emotional learning and memory were assessed with the fear conditioning test and spatial learning and memory with the Morris water maze. Finally, brains were processed for histology. Only one rat developed late spontaneous seizures (i.e., epilepsy). Epileptiform interictal spiking was detected in 9 of 26 animals. Early seizures did not predict the development of epilepsy, spiking activity, or severity of behavioral impairm
Who reads A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Heli Karhunen; Jari Nissinen; Juhani Sivenius; Jukka Jolkkonen; Asla Pitkänen
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)
More by Heli Karhunen; Jari Nissinen; Juhani Sivenius; Jukka Jolkkonen; Asla Pitkänen
Browse all works by Heli Karhunen; Jari Nissinen; Juhani Sivenius; Jukka Jolkkonen; Asla Pitkänen