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Cohesive, multicomponent, dense powder flow characterization by NIR by C. Benedetti; N. Abatzoglou; J.-S. Simard; L. McDermott; G. Léonard; L. Cartilier is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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Non-aerated powder flows are frequently encountered in downstream pharmaceutical processes. Such flows occur at the entrance of powder compression units, and their characteristics are of great interest because any powder agglomeration or segregation can be detrimental to the quality of the final solid oral dosage form. This work was aimed at developing a process analytical technology (PAT) method, based on near-infrared spectroscopy (NIR) for the in-line powder flow characterization of pharmaceutical formulations. An Ibuprofen drug formulation was selected for study. A bench-scale hopper system was assembled to monitor powder flow behaviour. An in-line commercial NIR Axsun spectrometer and probe were chosen to collect in-line spectral data on dense, multicomponent, non-aerated powder flow prior to compression. Spectra were collected on flowing mannitol and pharmaceutical product blends. A specially designed, non-contact sampling interface allowed the collection of representative process powder flow spectra without affecting blend uniformity. A partial least squares chemometric model was developed for laboratory-prepared samples, to quantitatively determine the flowing powder's acti

Who reads Cohesive, multicomponent, dense powder flow characterization by NIR?

Author

C. Benedetti; N. Abatzoglou; J.-S. Simard; L. McDermott; G. Léonard; L. Cartilier

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2007

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)