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Mobilization of the Innate Immune Response by a Specific Immunostimulant β-Glucan Confers Resistance to Chronic Stress-induced Depression-like Behavior by Preventing Neuroinflammatory Responses by Jie Ren; Yi Zhang; Hainan Pan; Ruiting Shi; Haojie Zhu; Rongrong Yang; Lin Zhang; Bingran Chen; Tao Zhu; Xu Lu; Chao Huang is a Immunology and Microbiology article available to read on EtoBox.

What is Mobilization of the Innate Immune Response by a Specific Immunostimulant β-Glucan Confers Resistance to Chronic Stress-induced Depression-like Behavior by Preventing Neuroinflammatory Responses about?

Pre-stimulation of the innate immune response is an effective strategy to prevent depression-like phenotypes in animals. However, the use of conventional immunostimulants may cause adverse effects. Therefore, the search for agents that stimulate the innate immune response but do not induce a pro-inflammatory response could be a new research direction for the prevention of depression. β-glucan is a polysaccharide from Saccharomyces cerevisiae with unique immunomodulatory activity in microglia without eliciting a pro-inflammatory response that could lead to tissue damage. This suggests that β-glucan may be a suitable drug that can be used to prevent depression-like phenotypes. Our results showed that a single injection of β-glucan 1 day before stress exposure at a dose of 10 or 20 mg/kg, but not at a dose of 5 mg/kg, prevented depression-like behavior in mice treated with chronic unpredictable stress (CUS). This effect of β-glucan disappeared when the time interval between β-glucan and stress was extended from 1 day or 5 days to 10 days, which was rescued by a second injection 10 days after the first injection or by a repeated injection (4×, once daily) 10 days before stress exposure

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Author

Jie Ren; Yi Zhang; Hainan Pan; Ruiting Shi; Haojie Zhu; Rongrong Yang; Lin Zhang; Bingran Chen; Tao Zhu; Xu Lu; Chao Huang

Publisher

Elsevier BV

Published

2024

Language

EN

Field

Immunology and Microbiology (Life Sciences)