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Porphyrin–phospholipid Interaction and Ring Metallation Depending on the Phospholipid Polar Head Type by Ana P. Ramos; Christiane Pavani; Yassuko Iamamoto; Maria E.D. Zaniquelli is a Chemistry article available to read on EtoBox.

What is Porphyrin–phospholipid Interaction and Ring Metallation Depending on the Phospholipid Polar Head Type about?

The interaction between a hydrophobically modified 5,10,15,20-tetrakis(4-N-tetradecyl-pyridyl) porphyrin and three phospholipids: two negatively charged, DMPA (the sodium salt of dimyristoyl-snglycero-phosphatidyl acid) and DMPG (the sodium salt of 1,2-dimyristoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]) and a zwitterionic DMPC (dimyristoyl-sn-glycero-phosphatidylcholine), were studied by means of surface pressure isotherms and spectroscopic methods. The interaction results in partial or total metallation of the porphyrin with zinc ions in the presence of negatively charged phospholipids, as attested by UV-vis and luminescence spectroscopy of the transferred films. In the presence of the zwitterionic phospholipid no insertion of zinc ion in the porphyrin ring is detected. These results are relevant for the understanding of photosensitizer-lipid-carrier binding for use in photodynamic therapy.

Who reads Porphyrin–phospholipid Interaction and Ring Metallation Depending on the Phospholipid Polar Head Type?

Author

Ana P. Ramos; Christiane Pavani; Yassuko Iamamoto; Maria E.D. Zaniquelli

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0021-9797)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)