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Combined Positron Emission Tomography/Computed Tomography in Sunitinib Therapy Assessment of Patients with Metastatic Renal Cell Carcinoma by M.E. Revheim; A.K. Winge-Main; G. Hagen; J.G. Fjeld; S.D. Fosså; W. Lilleby is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Combined Positron Emission Tomography/Computed Tomography in Sunitinib Therapy Assessment of Patients with Metastatic Renal Cell Carcinoma about?

Aim: To assess the clinical benefit of combined functional imaging with [ 18 F]2-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with metastatic renal cell carcinoma (mRCC) treated with the tyrosine kinase inhibitor sunitinib. Materials and methods: Fourteen patients with mRCC were prospectively enrolled in this study. All patients underwent PET/CT before receiving at least two cycles of sunitinib treatment. Three months after the onset of sunitinib treatment, a second PET/CT was carried out. The metabolic response evaluated from the PET (standard uptake value; SUV) was compared with the CT component of the PET/CT. The Response Evaluation Criteria in Solid Tumours criteria were used to assess the CT response and modified European Organization for Research and Treatment of Cancer criteria were used to assess the PET response. Results: Three main results were obtained: (1) Patients with relatively low 18F-FDG uptake before treatment (SUV < 5) had a longer progression-free survival than those with a relatively high 18F-FDG uptake (P 1⁄4 0.006). ( 2) Patients with a partial metabolic response or stable metabolic disease after two

Who reads Combined Positron Emission Tomography/Computed Tomography in Sunitinib Therapy Assessment of Patients with Metastatic Renal Cell Carcinoma?

Author

M.E. Revheim; A.K. Winge-Main; G. Hagen; J.G. Fjeld; S.D. Fosså; W. Lilleby

Publisher

Elsevier Science; Springer; Elsevier ; Springer-Verlag; W. B. Saunders Co., Ltd.; Springer Verlag; Elsevier BV; Springer Science and Business Media LLC (ISSN 1433-2981)

Published

2011

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)