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Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production by Pilar Sancho; Eva Galeano; Elena Nieto; M. Dolores Delgado; Ana Isabel García-Pérez is a Medicine article available to read on EtoBox.
What is Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production about?
Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells. Our aim was a better understanding of DQA cytotoxicity. DQA-induced NB4 and K562 cell alterations are initiated within the first 30 min of treatment at a high DQA concentration with a mitochondrial membrane depolarization. Cytochrome c release to cytoplasm, superoxide anion overproduction and ATP depletion in NB4 cells induce, 16 h later, apoptosis by a typical caspase-9/caspase-3-dependent intrinsic pathway. K562 cells were more resistant to the DQA effect than NB4 cells, remaining viable for longer time periods.
Who reads Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Pilar Sancho; Eva Galeano; Elena Nieto; M. Dolores Delgado; Ana Isabel García-Pérez
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0145-2126)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)