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Can I read Involvement of the Medial Septum in Stress-induced Relapse to Heroin Seeking in Rats on EtoBox?
Involvement of the Medial Septum in Stress-induced Relapse to Heroin Seeking in Rats by David Highfield; Alison Clements; Uri Shalev; Robert McDonald; Robert Featherstone; Jane Stewart; Yavin Shaham is a Neuroscience article available to read on EtoBox.
What is Involvement of the Medial Septum in Stress-induced Relapse to Heroin Seeking in Rats about?
Intermittent footshock stress has been shown to reinstate extinguished drug-taking behaviour in rats, but the brain areas involved in this effect are to a large degree unknown. Here we studied the role of the septum in stress-induced reinstatement of heroin seeking. Rats were trained to self-administer heroin for 9-10 days (three 3-h sessions per day, 0.1 mg/kg per infusion). Following training, extinction sessions were given for 8-13 days by substituting saline for heroin, and then tests for reinstatement of heroin seeking were carried out. Reversible inactivation of the medial septum with tetrodotoxin (TTX; 1-5 ng, infused 25-40 min before the test sessions) reliably reinstated heroin seeking, mimicking the effect of 15 min of intermittent footshock. This effect of TTX was not observed after infusions made 1.5 mm dorsally into the lateral septum. In other experiments, it was found that infusions of a low, subthreshold dose of TTX (0.5 ng) into the medial septum, when combined with 2 min of footshock that in itself was ineffective, reinstated heroin seeking. Furthermore, electrical stimulation (400 microA pulses, 100 micros duration, 100 Hz frequency) of the medial septum during e
Who reads Involvement of the Medial Septum in Stress-induced Relapse to Heroin Seeking in Rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- David Highfield; Alison Clements; Uri Shalev; Robert McDonald; Robert Featherstone; Jane Stewart; Yavin Shaham
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)
- Published
- 2000
- Language
- EN
- Field
- Neuroscience (Life Sciences)