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Reperfusion Damage to the Bile Canaliculi in Transplanted Human Liver by J C Cutrin; D Cantino; F Biasi; E Chiarpotto; M Salizzoni; E Andorno; G Massano; G Lanfranco; M Rizzetto; A Boveris; G Poli is a Medicine article available to read on EtoBox.

What is Reperfusion Damage to the Bile Canaliculi in Transplanted Human Liver about?

In 19 patients who have undergone orthotopic liver transplantation (OLT), the trend and degree of cholestasis was statistically monitored in terms of plasma levels of L-gamma-glutamyl transferase (GGT) and total bilirubin. In addition, the ultrastructure of the bile canaliculus was examined during the entire OLT procedure, i.e., during explantation, cold ischemia, and after 60 to 90 minutes of organ reperfusion. Cholestasis was evident from the second day after surgery, with a peak after approximately 10 to 16 days. Defined, small changes in the functional state of actin filaments were noted in the bile canalicular area after prolonged ischemia. But the morphological status of the bile canaliculi changed dramatically after reperfusion. In fact, the mean area and perimeter of the canaliculi had increased significantly, and there was a marked loss in the number of bile microvilli per unit of canalicular area. The bile canaliculus appears to be one of the liver structures most susceptible to ischemia-reperfusion damage. A series of biochemical changes occurring during ischemia and after reoxygenation of the transplanted liver, especially, would provide a reason for the observed early

Who reads Reperfusion Damage to the Bile Canaliculi in Transplanted Human Liver?

Author

J C Cutrin; D Cantino; F Biasi; E Chiarpotto; M Salizzoni; E Andorno; G Massano; G Lanfranco; M Rizzetto; A Boveris; G Poli

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

1996

Language

EN

Field

Medicine (Health Sciences)