About this document
AUC and Clearance in Pharmacokinetics by Manikanta Guptha is a document available to read on EtoBox.
Biopharmaceutical calculations are important to determine how much drug reaches systemic circulation and to determine dosing. Absorption of orally administered drugs is calculated using bioavailability, which is the fraction of the dose that reaches systemic circulation. Area under the curve (AUC) and clearance can be used to calculate bioavailability from dose or vice versa. Working examples demonstrate calculating bioavailability from AUC and dose, AUC from clearance, dose from a target AUC and clearance,
- Author
- Manikanta Guptha
- Language
- EN