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Can I read A β,β′-ketoaminoester as a valuable tool for the asymmetric construction of substituted homopipecolic esters: application to a formal synthesis of (+)-Calvine on EtoBox?
A β,β′-ketoaminoester as a valuable tool for the asymmetric construction of substituted homopipecolic esters: application to a formal synthesis of (+)-Calvine by Sophie Rougnon-Glasson; Christophe Tratrat; Jean-Louis Canet; Pierre Chalard; Yves Troin is a Chemistry article available to read on EtoBox.
What is A β,β′-ketoaminoester as a valuable tool for the asymmetric construction of substituted homopipecolic esters: application to a formal synthesis of (+)-Calvine about?
A highly diastereoselective 1,4-addition involving Davies' lithium amide is employed as the key reaction to prepare, in five steps from ethyl acetoacetate, an enantiomerically pure keto protected b,b 0 -ketoaminoester. This latter was reacted with aldehydes in an intramolecular Mannich process and furnished a direct and stereoselective access to substituted homopipecolates. The validity of this approach was achieved through a new formal asymmetric synthesis of alkaloid (þ)-Calvine.
Who reads A β,β′-ketoaminoester as a valuable tool for the asymmetric construction of substituted homopipecolic esters: application to a formal synthesis of (+)-Calvine?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Sophie Rougnon-Glasson; Christophe Tratrat; Jean-Louis Canet; Pierre Chalard; Yves Troin
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0957-4166)
- Published
- 2004
- Language
- EN
- Field
- Chemistry (Physical Sciences)