Can I read Thymidine phosphorylase facilitates retinoic acid inducible gene-I induced endothelial dysfunction on EtoBox?
Thymidine phosphorylase facilitates retinoic acid inducible gene-I induced endothelial dysfunction by Adrian Baris; Eugenia Fraile-Bethencourt; Jaiden Eubanks; Sokchea Khou; Sudarshan Anand is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Thymidine phosphorylase facilitates retinoic acid inducible gene-I induced endothelial dysfunction about?
Activation of nucleic acid sensors in endothelial cells (ECs) has been shown to drive inflammation across pathologies including cancer, atherosclerosis and obesity. We previously showed that enhancing cytosolic DNA sensing by inhibiting three prime exonuclease 1 (TREX1) in ECs led to EC dysfunction and impaired angiogenesis. Here we show that activation of a cytosolic RNA sensor, Retinoic acid Induced Gene 1 (RIG-I) diminishes EC survival, angiogenesis and triggers tissue specific gene expression programs. We discovered a RIG-I dependent 7 gene signature that affects angiogenesis, inflammation and coagulation. Among these, we identified the thymidine phosphorylase TYMP as a key mediator of RIG-I induced EC dysfunction via its regulation of a subset of interferon stimulated genes. Our RIG-I induced gene signature was also conserved in the context of human diseases – in lung cancer vasculature and herpesvirus infection of lung endothelial cells. Pharmacological or genetic inhibition of TYMP rescues RIG-I induced EC death, migration arrest and restores sprouting angiogenesis. Interestingly, using RNAseq we identified a gene expression program that was RIG-I induced but TYMP dependent.
Who reads Thymidine phosphorylase facilitates retinoic acid inducible gene-I induced endothelial dysfunction?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Adrian Baris; Eugenia Fraile-Bethencourt; Jaiden Eubanks; Sokchea Khou; Sudarshan Anand
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)