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A Nanofiber/sponge Double-layered Composite Membrane Capable of Inhibiting Infection and Promoting Blood Coagulation During Wound Healing by Zhongfei Gao; Qinbing Qi; Rongkai Li; Chengbo Li; Xianrui Xie; Guige Hou is a Materials Science article available to read on EtoBox.

What is A Nanofiber/sponge Double-layered Composite Membrane Capable of Inhibiting Infection and Promoting Blood Coagulation During Wound Healing about?

Uncontrolled bleeding and bacterial infections cause severe damage to the wounds and remain a clinical challenge. Here, we developed a nanofiber/sponge bilayered composite membrane (QCP) containing quaternized silicone (QP12) and quaternized chitosan (QCS12) by joint approaches of electrospinning and freeze-drying and investigated their potential for wound dressing. The QCP was composed of a sponge (QCC) containing collagen (COL) and QCS12 and a nanofibrous membrane (MQP) containing poly-ε-caprolactone (PCL) and QP12. The QCP composite membrane possessed feasible permeability (0.22 ± 0.01 g/(cm 2 ⋅24 h)), available thermal stability, suitable mechanical properties with natural skin, and in vivo hemostatic efficiency. The bonds of the N-quaternary and Schiff base endow composite membranes with significant anti-microbial invasion, potentially enhancing the wound healing process with an eligible microenvironment. Meanwhile, QCP evinced fine hemocompatibility, low cytotoxicity, negligible skin irritation, and other desirable biosafety as an excellent wound dressing. QCP promoted collagen deposition and re-epithelization to accelerate healing and suppress scars in the full-thickness acu

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Author

Zhongfei Gao; Qinbing Qi; Rongkai Li; Chengbo Li; Xianrui Xie; Guige Hou

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)