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Can I read Stage-independent Expression and Genetic Analysis of Tp73 in Neuroblastoma on EtoBox?
Stage-independent Expression and Genetic Analysis of Tp73 in Neuroblastoma by Massimo Romani; Paola Scaruffi; Ida Casciano; Katia Mazzocco; Crocifissa Lo Cunsolo; Andrea Cavazzana; Claudio Gambini; Luca Boni; Bruno De Bernardi; Gian Paolo Tonini is a Medicine article available to read on EtoBox.
What is Stage-independent Expression and Genetic Analysis of Tp73 in Neuroblastoma about?
The tp73 gene, a tp53 homologue, has been sub-regionally mapped at 1p36.3, a chromosomal region frequently deleted in neuroblastoma. Due to its chromosomal localization and to the mono-allelic expression observed in some neuroblastoma cell lines, it was proposed that tp73 might be involved in the pathogenesis of neuroblastoma. Functional assays have demonstrated that tp73 can inhibit cell proliferation and induce apoptosis. The role of this gene in tumorigenesis, however, is still unclear. We analyzed tp73 expression in 95 sporadic neuroblastoma samples by RT-PCR and we detected the tp73 transcript in 46 cases (48.4%), without significant correlation with age, clinical stage or 3-year overall survival. A genetic polymorphism in the 2nd exon of tp73 was utilized to identify the transcribed allele in tumor-cell samples. Expression from only one of the tp73 alleles was found in 13 out of 16 heterozygous tumors, while in 3 samples both alleles were present. Genotype analysis of 73 patients and 150 controls showed a significant deviation (p ؍ 0.0308) from the Hardy-Weinberg equilibrium for a tp73 allele only among neuroblastoma patients. The absence of correlation between tp73 express
Who reads Stage-independent Expression and Genetic Analysis of Tp73 in Neuroblastoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Massimo Romani; Paola Scaruffi; Ida Casciano; Katia Mazzocco; Crocifissa Lo Cunsolo; Andrea Cavazzana; Claudio Gambini; Luca Boni; Bruno De Bernardi; Gian Paolo Tonini
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)