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The study presents a novel trispecific killer engager (TriKE) targeting B7-H3 that enhances natural killer (NK) cell antitumor activity against head and neck squamous cell carcinoma (HNSCC), particularly in patients with HPV-negative tumors. The B7H3 TriKE effectively overcomes the suppressive tumor microenvironment by delivering dual signals to NK cells, resulting in improved cytotoxicity and prolonged survival in preclinical models. This promising immunotherapeutic approach shows potential for advancing N

Author

Peeranut Winidmanokul

Language

EN