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Lipid metabolism genetic risk score interacts with the Brazilian Healthy Eating Index Revised and its components to influence the odds for dyslipidemia in a cross-sectional population-based survey in Brazil by Tatiane Mieko de Meneses Fujii; Marina Maintinguer Norde; Regina Mara Fisberg; Dirce Maria Lobo Marchioni; Marcelo Macedo Rogero is a Medicine article available to read on EtoBox.
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## Background: Dyslipidemia can be influenced by genetic and dietary risk factors. ## Aim: This study set out to investigate diet and genetic variations in brazilian people in a cross-sectional population-based survey and to analyze the relationship between single nucleotide polymorphisms (snps) of genes involved in lipid metabolism and cardiometabolic-related phenotypes using a genetic risk score (grs). ## Methods: We recruited 228 adults (mean age 36.5 years) who participated in the health survey of são paulo (hs-sp), brazil. clinical and anthropometric parameters, as well as the interaction between the grs and the brazilian healthy eating index revised (bhei-r) were evaluated. we analyzed the relationship between snps in apoa5 (rs662799), apob (rs693, rs1367117), ldlr (rs688, rs5925) and lipc (rs2070895, rs1800588) and cardiometabolic-related phenotypes using a grs. ## Results: High-density lipoprotein cholesterol (hdlc) levels were associated with the bhei-r ( p=0.026; β= -0.183) and with its sofaas component (solid fats, alcoholic beverages and added sugars) ( p=0.007; β=0.279). non-hdl cholesterol levels were associated with the bhei-r vegetable component ( p=0.015; β=0.002)
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- Author
- Tatiane Mieko de Meneses Fujii; Marina Maintinguer Norde; Regina Mara Fisberg; Dirce Maria Lobo Marchioni; Marcelo Macedo Rogero
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)