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Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation by Kyung-Ah Cho; Je-Eun Cha; Jungwoo Kim; Yu-Hee Kim; Kyung-Ha Ryu; So-Youn Woo is a Medicine article available to read on EtoBox.

What is Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation about?

## Background: Mast cells are immune sentinels in the skin that respond to a wide range of pathological and environmental stimuli; they owe their function to the expression of toll-like receptors (tlrs). we previously found that tonsil-derived mesenchymal stem cells (t-mscs) were able to effectively attenuate tlr7-mediated skin inflammation in mice, which was accompanied by an increase in mast cell number. the present study investigated whether t-msc extracellular vesicles, such as exosomes, are able to regulate mast cell activation in response to tlr7 stimulation. ## Methods: The hmc-1 human mast cell line was treated with a tlr7 agonist in the presence or absence of t-msc exosomes, and the levels of expressed inflammatory cytokines were assessed. additionally, mice were repeatedly injected with a tlr7 agonist with or without interval treatments with t-msc exosomes and assessed dermal distribution of mast cells and related immune cells. ## Results: We showed that t-msc exosomes containing micrornas that target inflammatory cytokines significantly reduced the expression of inflammatory cytokines in tlr7 agonist-treated hmc-1 cells. in addition, t-msc exosomes inhibited the increase

Who reads Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation?

Author

Kyung-Ah Cho; Je-Eun Cha; Jungwoo Kim; Yu-Hee Kim; Kyung-Ha Ryu; So-Youn Woo

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)