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Radical scavenging and angiotensin converting enzyme inhibitory activities of standardized extracts of Ficus racemosa stem bark by Faiyaz Ahmed; Jalahalli M. Siddesha; Asna Urooj; Bannikuppe S. Vishwanath is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The present study evaluated the radical scavenging and angiotensin converting enzyme (ACE) inhibitory activity of cold and hot aqueous extracts of __Ficus racemosa__ (Moraceae) stem bark. The extracts were standardized using HPLC. Radical scavenging activity was determined using 1,1‐diphenyl‐2‐picrylhydrazyl radical and angiotensin converting enzyme inhibitory activity using rabbit lung and partially purified porcine kidney ACE. HPLC profiles of cold aqueous extract (FRC) showed the presence of bergenin, an isocoumarin, while hot aqueous extract (FRH) was found to contain ferulic acid, kaempferol and coumarin in addition to bergenin. FRH showed significantly higher (__p__ ≤ 0.01) radical scavenging activity than FRC and butylated hydroxytoluene (BHT), consequently resulting in a significantly lower (__p__ ≤ 0.01) IC~50~ value than FRC and BHT. Both the extracts exhibited a dose dependent inhibition of porcine kidney and rabbit lung ACE. FRH showed significantly higher (__p__ ≤ 0.01) activity than FRC with lower IC~50~ values of 1.36 and 1.91 μg/mL respectively, for porcine kidney and rabbit lung ACE, compared with those of FRC (128 and 291 μg/mL). Further, a significant

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Author

Faiyaz Ahmed; Jalahalli M. Siddesha; Asna Urooj; Bannikuppe S. Vishwanath

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)