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Can I read Biotransformation of Xenobiotics by Amine Oxidases on EtoBox?
Biotransformation of Xenobiotics by Amine Oxidases by Margherita Strolin Benedetti is a Medicine article available to read on EtoBox.
What is Biotransformation of Xenobiotics by Amine Oxidases about?
Although the cytochrome P450 (CYP) system ranks first in terms of catalytic versatility and the wide range of xenobiotics it detoxifies or activates to reactive intermediates, the contribution of amine oxidases and in particular of monoamine oxidases (MAOs) to the metabolism of xenobiotics is far from negligible but has been largely neglected. In this review on the involvement of amine oxidases in the metabolism of xenobiotics, the major characteristics reported for the CYP system (protein, reaction, tissue distribution, subcellular localisation, substrates, inhibitors, inducers, genetic polymorphism, impact of different physiopathological conditions on the activity, turnover) will be compared, whenever possible, with the corresponding characteristics of amine oxidases (MAOs in particular). The knowledge of the involvement of MAO‐A, ‐B or both in the metabolism of a drug allows us to predict interactions with selective or non‐selective MAO inhibitors (e.g. the metabolism of a drug deaminated by both forms of MAO is not necessarily inhibited in vivo by a selective MAO‐A or ‐B inhibitor). If a drug is metabolized by MAOs, competitive interactions can occur with other drugs that are M
Who reads Biotransformation of Xenobiotics by Amine Oxidases?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Margherita Strolin Benedetti
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0767-3981)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)