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Thiopurine S ‐methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease by R. B. Gearry; M. L. Barclay; M. J. Burt; J. A. Collett; B. A. Chapman; R. L. Roberts; M. A. Kennedy is a Medicine article available to read on EtoBox.
What is Thiopurine S ‐methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease about?
## Summary **Background** : Azathioprine and mercaptopurine (MP) are well established treatments for inflammatory bowel disease but they have severe adverse effects that prevent their use in some patients. The likelihood and type of adverse effect may relate to thiopurine methyltransferase (TPMT) enzyme activity and genotype. **Aim** : To compare the __TPMT__ genotype frequencies in patients with inflammatory bowel disease who have had severe adverse effects to those who tolerate azathioprine or MP (controls). **Methods** : Patients with inflammatory bowel disease who had been treated with azathioprine or MP in Christchurch between 1996 and 2002 were identified. Patients with adverse effects, and controls, were invited to provide a peripheral blood sample for analysis of __TPMT__ genotype. The genotype frequencies were then compared between the two groups. **Results** : Fifty‐six patients were identified with adverse effects requiring cessation of therapy, of which 50 were genotyped. Reactions included allergic‐type (25%), hepatitis (33%), nausea/vomiting (14%), bone marrow suppression (10%), pancreatitis (6%) and other (12%). Five of 50 patients with reactions had __TPMT__ genotyp
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- Author
- R. B. Gearry; M. L. Barclay; M. J. Burt; J. A. Collett; B. A. Chapman; R. L. Roberts; M. A. Kennedy
- Publisher
- John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)