Opening book details…
Can I read Protective effects of lemongrass (Cymbopogon citratus STAPF) essential oil on DNA damage and carcinogenesis in female Balb/C mice on EtoBox?
Protective effects of lemongrass (Cymbopogon citratus STAPF) essential oil on DNA damage and carcinogenesis in female Balb/C mice by Lucas T. Bidinotto; Celso A. R. A. Costa; Daisy M. F. Salvadori; Mirtes Costa; Maria A. M. Rodrigues; Luís F. Barbisan is a Environmental Science article available to read on EtoBox.
What is Protective effects of lemongrass (Cymbopogon citratus STAPF) essential oil on DNA damage and carcinogenesis in female Balb/C mice about?
## Abstract This study investigated the protective effect of oral treatment with lemongrass (__Cymbopogon citratus__ STAPF) essential oil (LGEO) on leukocyte DNA damage induced by __N__‐methyl‐__N__‐nitrosurea (MNU). Also, the anticarcinogenic activity of LGEO was investigated in a multi‐organ carcinogenesis bioassay induced by 7,12‐dimethylbenz(a)antracene, 1,2‐dimethylhydrazine and __N__‐butyl‐__N__‐(4‐hydroxibuthyl)nitrosamine in Balb/C female Balb/c mice (DDB‐initiated mice). In the short‐term study, the animals were allocated into three groups: vehicle group (negative control), MNU group (positive control) and LGEO 500 mg kg^−1^ (five times per week for 5 weeks) plus MNU group (test group). Blood samples were collected to analyze leukocyte DNA damage by comet assay 4 h after each MNU application at the end of weeks 3 and 5. The LGEO 500 mg kg^−1^ treated group showed significantly lower (__P__ < 0.01) leukocyte DNA damage than its respective positive group exposed to MNU alone at week 3. In the medium‐term study, DDB‐initiated mice were allocated into three groups: vehicle group (positive control) and LGEO 125 or 500 mg kg^−1^ (five times per week for 6 weeks; test groups). At
Who reads Protective effects of lemongrass (Cymbopogon citratus STAPF) essential oil on DNA damage and carcinogenesis in female Balb/C mice?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Lucas T. Bidinotto; Celso A. R. A. Costa; Daisy M. F. Salvadori; Mirtes Costa; Maria A. M. Rodrigues; Luís F. Barbisan
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)
- Published
- 2010
- Language
- EN
- Field
- Environmental Science (Physical Sciences)