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Can I read Proteomic Analysis of Embryonic Stem Cell–derived Neural Cells Exposed to the Antidepressant Paroxetine on EtoBox?
Proteomic Analysis of Embryonic Stem Cell–derived Neural Cells Exposed to the Antidepressant Paroxetine by Patrick C. McHugh; Geraldine R. Rogers; Barbara Loudon; Dylan M. Glubb; Peter R. Joyce; Martin A. Kennedy is a Neuroscience article available to read on EtoBox.
What is Proteomic Analysis of Embryonic Stem Cell–derived Neural Cells Exposed to the Antidepressant Paroxetine about?
## Abstract Antidepressant drugs can have significant effects on the mood of a patient suffering from major depression or other disorders. The pharmacological actions of these drugs generally affect the uptake or metabolism of the neurotransmitters serotonin, noradrenalin, and, to a lesser extent, dopamine. However, many aspects of antidepressant action are not understood. We conducted a proteomic analysis in a neuronal cell culture model in an attempt to identify molecules important to the operation of pathways functionally relevant to antidepressant action. The model involved generating cultures containing mixed neural and glial cells by controlled differentiation of mouse embryonic stem cells, followed by exposure to 1 μM paroxetine for 14 days. After antidepressant exposure, we observed increased expression or modification of sepiapterin reductase (SPR), heat shock protein 9A, RAS and EF‐hand domain containing, and protein disulfide isomerase associated 3 and decreased expression or modification of creatine kinase, actin, prohibitin, a T‐cell receptor α chain, defensin‐related cryptdin 5, and the intermediate filament proteins glial fibrillary acidic protein and vimentin. SPR,
Who reads Proteomic Analysis of Embryonic Stem Cell–derived Neural Cells Exposed to the Antidepressant Paroxetine?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Patrick C. McHugh; Geraldine R. Rogers; Barbara Loudon; Dylan M. Glubb; Peter R. Joyce; Martin A. Kennedy
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2007
- Language
- EN
- Field
- Neuroscience (Life Sciences)