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A Systematic Assessment of the Association Between Frequently Prescribed Medicines and the Risk of Common Cancers: a Series of Nested Case-control Studies by McDowell, R. D. (author);Hughes, C. (author);Murchie, P. (author);Cardwell, C. (author) is a Medicine article available to read on EtoBox.
What is A Systematic Assessment of the Association Between Frequently Prescribed Medicines and the Risk of Common Cancers: a Series of Nested Case-control Studies about?
## Abstract ## Background Studies systematically screening medications have successfully identified prescription medicines associated with cancer risk. However, adjustment for confounding factors in these studies has been limited. We therefore investigated the association between frequently prescribed medicines and the risk of common cancers adjusting for a range of confounders. ## Methods A series of nested case-control studies were undertaken using the Primary Care Clinical Informatics Unit Research (PCCIUR) database containing general practice (GP) records from Scotland. Cancer cases at 22 cancer sites, diagnosed between 1999 and 2011, were identified from GP records and matched with up to five controls (based on age, gender, GP practice and date of registration). Odds ratios (OR) and 95% confidence intervals (CI) comparing any versus no prescriptions for each of the most commonly prescribed medicines, identified from prescription records, were calculated using conditional logistic regression, adjusting for comorbidities. Additional analyses adjusted for smoking use. An association was considered a signal based upon the magnitude of its adjusted OR, p-value and evidence of an ex
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- Author
- McDowell, R. D. (author);Hughes, C. (author);Murchie, P. (author);Cardwell, C. (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)